Aurizon 20 ml
VETERINARY USE ONLY
Ear drops suspension for dogs
Dexamethasone (as Dexamethasone Acetate)
Each drop of AURIZON contains 71 µg marbofloxacin, 237 µg clotrimazole and 23.7 µg dexamethasone acetate.
For the treatment of canine otitis externa associated with yeast (Malassezia pachydermatis) sensitive to clotrimazole and bacteria (Staphylococcus spp. (including S. intermedius), Pseudomonas aeruginosa, Proteus spp. and Streptococcus spp.) sensitive to marbofloxacin.
AURIZON combines three active ingredients:
- marbofloxacin, a synthetic bactericidal agent belonging to the fluoroquinolones family that acts by inhibiting DNA gyrase.
- clotrimazole, an anti-fungal agent that belongs to the imidazole family and which acts by causing changes in membrane permeability, allowing intracellular compounds to leak from the cell and thus inhibiting cellular molecular synthesis.
- dexamethasone acetate, a synthetic glucocorticoid exhibiting anti-inflammatory and anti-pruritic activity.
When AURIZON was applied to healthy dog ears, marbofloxacin was absorbed percutaneously resulting in a mean plasma concentration of 0.06 µg/mL on the 14th day of treatment, which is 5.8 times less than the mean minimal plasma concentration observed after 7 days of marbofloxacin oral administration at the therapeutic dose of 2 mg/kg. Clotrimazole was poorly absorbed and was not detectable (