Avimec Super 50 ml
Each 1ml contains:
Ivermectin 10 mg
Clorsulon 100 mg
Ivermectin against the parasites is related to the inhibition of the parasite motility. B1a apparently increases the release of d-aminobutyric acid (GABA) from the synaptosomes of the nervous system.
The normal function of GABA in tested mammals and invertebrates is inhibition of neurotransmission.
Increasing release of GABA increases the normal resting potential of postsynaptic cells making it difficult for neurotransmission of stimuli to muscles and muscle cells do not contract.
Although paralysis is the most evident effect of Ivermectin, suppression of the reproductive function has been observed in ticks. It does not result in prompt death or detachment of ticks but does interrupt feeding, molting and egg production, so that reducing the reproductive potential of ticks.
Ivermectin displays no activity against cestodes or trematodes due to these parasites do not utilize GABA as a neurotransmitter.
Clorsulon inhibits the enzymes implicated in the glycolytic pathway, source of energy in flukes.
Further investigations indicated that clorsulon is a competitive inhibitor of 8-phosphoglycerate kinase and phospho-glyceromutase and blocks the oxidation of glucose to acetate and propionate. Clorsulon also depresses ATP levels in the fluke.